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Such studies can only be used as indications for the impact upon the fertility status of males and females as it pertains to effects on, and function of, the reproductive tract organs if extensive histopathology assessment is undertaken.

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In the subchronic study foreign body pneumonia was observed at higher doses, rendering them sensitive to local effects.

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Full histopathology on all rats and on controls and high dose mice; nasal cavity for low dose mice.

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